Muscles and Nervous System gets in danger and weak by Cholesterol -Lowering Drugs.

Keeping LDL cholesterol in check is one of several ways to lower your risk of heart disease and stroke. Lifestyle changes, including a healthier diet and physical activity, may lower cholesterol in some people, while for others medication may also be required.

A team of researchers looked into the question of how bad white fat cells, which form the layer of fat under our skin, become good brown fat cells. Having conducted cell culture experiments, they found out that the biochemical pathway responsible for producing cholesterol plays a central role in this transformation.

Statin-induced drugs that are prescribed to individuals with high levels of cholesterol may weaken the patient’s muscles and nervous system, a study has observed.

Regular use of junk food and lack of an exercise regime has put urban kids at increased risk of high cholesterol levels.

The liver produces cholesterol our bodies need to function properly. It’s when we have too much cholesterol in the blood that problems can arise. Statins are a class of drugs that reduce cholesterol production in the liver. “Statins have the best evidence in terms of reducing cardiovascular event rates,” said endocrinologist Anne Carol Goldberg, M.D., professor of medicine at Washington University School of Medicine in St. Louis.

According to the research, which has been published in the journal Cell Metabolism, statin reduces the formation of brown adipose tissue which helps to convert sugar and fat into heat. People with brown adipose tissue are better at regulating their body temperature in the winter and are less likely to suffer from excess weight or diabetes.

Statins disrupt the production of cholesterol by blocking a specific enzyme inside cholesterol-producing liver cells. This results in more cholesterol-containing particles being removed from the bloodstream by the liver. Some statins also reduce the inflammatory process caused by elevated cholesterol within blood vessel walls. When the body has a reduced reaction to the invading cholesterol, fewer macrophages are allowed to travel into the artery walls, where they would have formed foam cells and plaque.

A team of researchers looked into the question of how bad white fat cells, which form the layer of fat under our skin, become good brown fat cells. Having conducted cell culture experiments, they found out that the biochemical pathway responsible for producing cholesterol plays a central role in this transformation. They also discovered that the key molecule regulating the transformation is the metabolite geranylgeranyl pyrophosphate.

They also studied positron emission tomography scans of 8,500 patients. This let them determine whether the person had brown adipose tissue. It was also known whether the patients were taking statins. Evaluating the scans shows that 6 per cent of those not taking the medication had brown adipose tissue, but this tissue type was present in only a little over 1 per cent of those who were taking statins.

The researchers conducted a separate clinical study of 16 people to demonstrate that statins reduce the activity of brown adipose tissue.

“We also have to consider that statins are incredibly important as a way to prevent cardiovascular disease. They save millions of lives around the world, and they are prescribed for a very good reason,” said Christian Wolfrum, a researcher. However, statins also have another negative effect: in high doses, they slightly increase some people’s risk of developing diabetes – as has been shown in other studies.

Metabolism can boost upto 2 days with 1 hour run on Treadmill: Research

The findings showed that a single bout of exercise for mice could boost the activity of energy-burning neurons and inhibit the counterpart one for up to two days and those changes can last longer with more training.

A single workout session consisting of three 20-minute treadmill runs could activate neurons that are important regulators of blood glucose levels and energy balance as well as influence metabolism for up to two days, says a study over mice.

“The study predicts that getting out and exercising even once in a semi-intense manner can reap benefits that can last for days, in particular with respect to glucose metabolism,” he added.Roughly 46 percent of people spend most of the workday sitting, and studies have shown that walking 1 mph burns well over twice as many calories as sitting for the same time period––191 calories versus 72 calories per hour, respectively. Further, a single workout consisting of three 20-minute treadmill runs caused a decrease in appetite that lasted up to six hours.”This result may explain at the neural circuit level why many people don’t feel hungry immediately after exercise,” Williams said.In the study, 24 participants completed the different cognitive tests while sitting, standing and walking at a self-imposed pace of roughly 1.4 mph and a faster pace of 2.1 mph. Working memory was slightly impaired during the test where participants had to recall numbers they’d just been shown in a series.
One of the neuron types is associated with reduced appetite, lower blood glucose levels, and higher energy burning when activated while the other type increases appetite and diminishes metabolism when activated.The study also provides avenue to research potential treatments to improve glucose metabolism in patients with conditions such as diabetes.”It is possible that activating melanocortin neurons may hold therapeutic benefits for patients one day, especially for diabetics who need improved blood-glucose regulation,” Williams said.”This research is not just for improving fitness. A better understanding of neural links to exercise can potentially help a number of conditions affected by glucose regulation,” he noted.
People who use the walking workstations see a significant boost in memory recall, even after having used them at a relatively relaxed pace for a short length of time. That’s according to a study published in the latest edition of the journal Computers in Human Behavior.

OBESE PEOPLE AT INCREASED RISK OF DEPRESSION

The recently published research paper in the international journal of epidemiology shows how being overweight causes psychological impact on body in spite of physiological illness such as cardiovascular diseases or even diabetes.

Symptoms of depression include increased appetite, reduced activity and weight gain. Both depression and obesity have strong genetic links. Therefore children of people with either or both problems have more chance to have them as well.

The research states, increase in BMI doesn’t just increase risk of cardiovascular and chronic disorders but also it may lead to depression.

For the study, the researchers looked at UK Bio bank data. From more than 48,000 people with depression, comparing them with a control group of more than 290,000 people who were born between 1938 and 1971, who provided medical and genetic information.

To determine that whether the people were having depression hospital data and self reportings were used. Genetic approach used to find link between these two. It was that people with higher BMI had low active genes for chronic disorders but more unstable mind set.

Child Malnutrition in Quetta: UNICEF official

40 to 65 percent of children in some parts of Quetta suburbs, aged between six months and five years are suffering from severe acute malnutrition. A nutrition officer from UNICEF Dr. Faisal revealed this to DawnNewsTV on Sunday.

“The worst areas are Quetta’s Panjpai tehsil and Kahan in terms of undernourishment,” he said.

In a study from Quetta, Baluchistan , it was reported that one out of two (48%) children were stunned and 10% were wasted. In another study Ansari highlighted that 22% children were stunned, 10% were wasted, and 24% were underweight in urban areas of Pakistan.

A joint screening in Quetta was conducted, between UNICEF and Balochistan government’s health department Pishin and Killa Abdullah districts of the province. Over 2,500 teams were formed to screen children from December 5 to 8, according to Dr Sher Ahmed Satakzai, the provincial coordinator for Balochistan’s lady health workers programme.

In view of severe drought-like conditions, the Balochistan government has already declared an emergency in 14 districts of the province. The government has decided to conduct a screening of children in drought-hit districts as well including Chaghi, Noshki, Washuk and Kharan, DrSatakzai said, adding that lady health workers would be tasked with carrying out the job.

Only one study has been carried out in the provincial capital Quetta, Baluchistan, and none of the research on child malnutrition was carried out in Gilgit Baltistan, Azad Jammu Kashmir, and Federally Administrated Tribal Areas (FATA).

Medical experts believe poverty, a lack of clean water and inappropriate food are the primary underlying reasons behind acute malnutrition.

World Health Organisation principles dictate that an emergency be declared when the number of malnourished children reaches 15pc, Dr Faisal said.

Province-wide numbers

Over 30,000 children below the age of five years have been found severely malnourished across the province during a separate screening process conducted by a nutrition cell over the course of the last two years. “Over 100,000 mothers were found anaemic,” he said.Ghulam Mustafa, the deputy manager of the nutrition cell said a screening of over 400,000 children and 200,000 pregnant and breastfeeding mothers was conducted in the province.

How good is Yogurt actually for your health ?

Lot’s of sugar on its way…

How many times have you had yogurt for breakfast or as a snack this week ? A lot ? Well…same.

Yogurt is , for sure , considered to be super-healthy. Have you seen how many varieties they stock at Whole Foods ?

“I’m obsessed with frozen yogurt because you don’t feel totally guilty eating it. It’s not as bad as ice cream, and during the hot summer months, it’s a great way to just refresh.”Says Caroline Sunshine.

But is yogurt really good for you, given how much sugar it has?

The short version: yes. “Considering it’s packed with probiotics, calcium, potassium, and protein, yogurt is one of the healthiest foods you can eat,” says Karen Ansel, R.D.

Yogurt Also has two kinds: Regular or greek

Greek yogurt is made by straining out the extra whey in regular yogurt. It makes a yogurt that’s thicker, creamier and tangier than regular yogurtPlain Greek yogurt has less sugar and more protein than regular yogurt. But regular yogurt delivers twice the bone-strengthening mineral calcium.

While people are REALLY obsessed with Greek yogurt, it is actually pretty similar nutritionally to regular yogurt. (You can see how eight ounces of plain, low-fat yogurt and plain, low-fat Greek yogurt compare in the infographic below.)

Here’s been chatter about the environmental impact of Greek yogurt’s byproduct, whey. When Greek yogurt is strained, the whey from the milk (also called “acid” whey because of its lower pH) is left over. The whey can be sold to farmers to add to livestock feed, and can also be used as fertilizer and even turned into electricity.

Because Greek yogurt production has increased so rapidly in recent years, there’s been some concern that farms don’t have the capacity to handle all the extra whey produced. They can use some of the whey productively, but the large quantities produced are too much. More research is currently being done on more efficient and new ways to handle the byproduct.

However, flavored yogurts (whether they’re regular or Greek) often contain added sugars and sweeteners that will take the carbohydrates and sugar counts way up. Skip those and add your own in the form of fruit, cinnamon, honey, or maple syrup if needed. 

Which to Choose:

Go Greek! The high-protein yogurt makes a more filling and hearty snack. It’s also great added to smoothies or mixed with fruit and whole-grain cereal for breakfast. Not to mention, plain Greek yogurt can be used in place of sour cream to save 78 calories and 7 grams of saturated fat (per ¼ cup) when making tacos, dips or baked potatoes.

 

Cool, so what are the actual health benefits of yogurt?

To be clear, you can get way more from a cup of yogurt than just calcium and protein. It also contains “good bacteria” that support your gut and immune system. “[Probiotics] have been credited with everything from improving digestion, to boosting immune health, to protecting against depression,” says Ansel.

Plus, some studies have suggested that four weeks of regularly eating probiotic yogurt is good for your brain, while another large study credited the healthy bacteria in yogurt for lowering risk of heart attack and stroke among people who ate just two servings a week. Not bad, not bad at all. 

It gets better: A 2012 study of over 120,000 people who weren’t obese and didn’t suffer from chronic disease found that regularly eating yogurt might protect against weight gain, possibly due to changes in gut bacteria. Woot!

How many calories we burn while walking ?

Walking–an effective way to burn calories.

YES.You heard it right.Merely walking a distance can help you burn calories.
Walking is a low-impact aerobic exercise that is easy to do,requires no special equipment and burns calories effectively.Your weight and the distance you walk are the biggest factors in determining how many calories you burn while walking.Studies have proven that an average person,walking continuously for an hour whether outdoor in a park or indoor on a treadmill burns approximately 300 calories.
Yes 300 calories in 60 minutes.Seems easy? Give it a try and feel the difference.
Some of the lifestyle changes you can adopt to walk for at least 60 minutes (if you don’t have enough time)
* Do not use vehicles while going to a nearby shop,prefer walking.
* Do not use lift for going to 1st or 2nd floor,instead climb the stairs

* Get up and walk around while making a call
* Clean your household
Adopt these habits and feel the change in your body.
Is it necessary to burn calories ?
Eating more calories than your body burns invites various health problems such as weight gain and higher body fat percentage.
High calorie intake will cause stress on our body.It can increase the risk of digestive problems,type-2 diabetes,heart diseases,cancer,etc.
Therefore,to maintain healthy body and to stay away from deadly diseases it is very much necessary to burn excessive calories

 

Keep walking and stay healthy !
#Healthnagri – Care that never ends.